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ACUTE RESPONSE OF THE RAT INCISOR BY SINGLE AND FRACTIONATED IRRADIATION

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Abstract

¹æ»ç¼±Á¶»ç°¡ ¾Ç¼ºÁ¾¾çÀÇ Ä¡·á¹ýÀ¸·Î½á ¿ì¼öÇÑ È¿°ú¸¦ °¡Áö°í ÀÖÀ½Àº ÁÖÁöÀÇ »ç½ÇÀÌ´Ù.
ÀúÀÚ´Â µÎ°æºÎ ¹æ»ç¼±Á¶»ç°¡ ¼ºÀå±â Ä¡¾Æ¹ßÀ°¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» ¿¬±¸Çϱâ À§ÇÏ¿© ÀýÄ¡ºÎ¿¡
Co-60 ¹æ»ç¼±Á¶»ç¿¡ ÀÇÇÑ ´ÜÀÏ ¹× ºÐÇÒÁ¶»ç 1ÁÖ, 2ÁÖ, 3ÁÖ, 4ÁÖÈÄ¿¡ ³ªÅ¸³ª´Â ±Þ¼º¹ÝÀÀÀ» ¹æ
»ç¼±ÇÐÀû ¹× Á¶Á÷ÇÐÀûÀ¸·Î °üÂûÇÏ¿´´ø ¹Ù ´ÙÀ½°ú °°Àº °á·ÐÀ» ¾ò¾ú´Ù.
1. Á¶»ç¹ÞÀº ¸ðµç ½ÇÇ豺¿¡¼­ Ä¡¾ÆÀÇ ¸ÍÃâ¼Óµµ°¡ Áö¿¬µÇ¾úÀ¸¸ç ¼Õ»óºÎÀ§¿¡´Â dentin niche
¿Í °ñ¼º»ó¾ÆÁú ¹× »ó¾ÆÁú·ùÀÇ Çü¼ºÀÌ ³ªÅ¸³µ´Ù.
2. ½Ã°£ÀÌ °æ°úÇÔ¿¡ µû¶ó Ä¡¼ö°­ÀÇ °ñ¼º»ó¾ÆÁú, »ó¾ÆÁú·ùÀÇ Ä§ÂøÀÌ Áõ°¡ÇÏ¿´´Ù.
3. ´ÜÀÏÁ¶»ç±ºÀÇ 500cGy, 1000cGy, 1500cGyÀÇ ½ÇÇ豺Àº ¼±·®À» ¸¹ÀÌ ¹ÞÀ»¼ö·Ï ¼Õ»óÀÌ ÄÇ
À¸¸ç ºÐÇÒÁ¶»ç±ºÀÇ 1000cGy, 1500cGy½ÇÇ豺Àº °°Àº¾çÀ» ¹ÞÀº ´ÜÀÏ Á¶»ç±ºº¸´Ù ¼Õ»óÀÌ ÇöÀú
ÇÏ°Ô Àû¾ú´Ù.
4. 500cGy ´ÜÀÏÁ¶»ç±º¿¡¼­´Â ȸº¹ÀÌ °¡´ÉÇÑ ÀϽÃÀû ¼Õ»óÀ» ÀÔ¾úÀ¸¸ç 1000cGy ´ÜÀÏÁ¶»ç±º
¿¡¼­´Â »ó´çÇÑ ¼Õ»ó°ú ÇÔ¿¡ 500cGy ´ÜÀÏÁ¶»ç±ºº¸´Ù ÀúÇÏµÈ ¼ºÀå¼Óµµ¸¦ ³ªÅ¸³Â´Ù. 1500cGy
´ÜÀÏÁ¶»ç±ºÀº °³ÀúÃþÀÌ Æı«µÇ¾î ¼ºÀåÀÌ Á¤Ã¼µÇ¾î ÀÖ´Â ¼Ò°ßÀ» º¸¿´´Ù.
5. ºÐÇÒÁ¶»ç±ºÀº ÁÖ´ç 500cGy¸¦ Á¶»ç ¹Þ¾Ò´Âµ¥ Á¶»ç °£°Ý±â¿¡ ȸº¹À» ÀÎÁöÇÒ ¼ö ÀÖ¾úÀ¸
¸ç Á¶»ç ȸ¼ö¸¦ °ÅµìÇÒ¼ö·Ï ¼Õ»óÀÇ ´©ÀûÈ¿°ú¸¦ º¸¿´À¸³ª ±× ¼Õ»óÀÇ Á¤µµ´Â 1000cGy,
1500cGy ´ÜÀÏÁ¶»ç±ºÀÇ °æ¿ìº¸´Ù Àû¾ú´Ù.
#ÃÊ·Ï#
Six to eight-month-old female albino rats were used as experimental animals. As an
irradiation equipment, a Co-60 was used.
The experimental animals were divided to; 6 of the control group, 12 of the 500cGy
single irradiation group, 12 of the 1000cGy fractionated irradiation group, and 12 of the
1500cGy fractionated irradiation group.
From the first week to the forth, 3 rats were picked from each group every week to
be sacrificed and fixed with formalin.
Those rats were observe d by means of H-E stain after being taken radiograph and
decalcified. The analysis of radiographic findings and light microscopic findings gives
results as follows:
1. The delay of dental eruption rate was found in every group which underwent the
irradiation experiment. Dentin niche, osteodentin, and dentin island were formed in the
parts which were damaged by the irradiation.
2. The longer the observation period was, the more deposit of osteodentin and dentin
island was formed.
3. In the single irradiation group, the damage effect was in proportion to the increase
of radiation dose, whereas the damage was much less in the fractionated group
receiving the same dose.
4. The 500cGy single irradiation group got temporary repairable damage, while the
1000cGy single irradiation group got considerable damage and showed much slower
eruption rate than the 500cGy single irradiation group. The basal portion of the 1500cGy
single irradiation group, whose growth was arrested, was destroyed.
5. The fractionated group were irradiated 500cGy everyweek. Repair was visible
during the interval periods. The damage was accumulated as irradiation repeated, but
degree of damage was lower than that of the 1000cGy and 1500cGy single irradiation
group.

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